
He played soccer in school and was named to the all-star team (prep school category) during his senior season. Soffer boarded at The Gunnery, graduating in 2003. Soffer spent part of his childhood in Tarrytown, New York, and later moved to Newtown, Connecticut, at age 10. He also has two older half-siblings from his father's first marriage, Craig and Melissa Soffer. Soffer has two younger half-sisters, Shayne and Jenna Hindes, from his mother's second marriage. His father died in 1993, when he was nine-years-old.

Jesse Lee Soffer was born in Ossining, New York to Jill Hindes (née Bruning) and Stan Soffer.

He is also known for his role as Bobby Brady in the comedy The Brady Bunch Movie and its sequel A Very Brady Sequel. crossover episodes with Chicago Med and Chicago Fire, as part of the main cast. From 2014 to 2022, he starred as Jay Halstead on the NBC drama Chicago P.D. He is known for portraying Will Munson on the CBS soap opera As the World Turns, and received three Emmy nominations for his work on the show. Jesse Lee Soffer is an American actor and television director.